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Association between TESC gene expression and clinical prognosis. A High and low expression groups, established by dividing the TCGA-LIHC on the basis of median expression of CD133, CD90, and EpCAM. Thirteen intersecting differentially expressed genes were identified, with high expression of TESC and QSOX1 being noted in LCSCs from spheroid cultures. B TESC’s high expression in the TCGA-LIHC was significantly correlated with shorter overall survival (OS). C TESC expression in various cancers compared with that in <t>adjacent</t> normal tissues (if available), assessed using TIMER2.0. D RNA expression of the TESC gene in <t>liver</t> <t>cancer</t> and normal liver tissues from the ICGC database. E Protein expression of the TESC gene in liver cancer and normal liver tissues from the CPTAC database. F Immunohistochemistry (IHC) image of TESC in liver cancer and adjacent liver tissues of <t>tissue</t> microarray (Cat. LV1505a, TissueArray.Com). Scale bar, 60 μm. * P < 0.05; ** P < 0.01; *** P < 0.001
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Association between TESC gene expression and clinical prognosis. A High and low expression groups, established by dividing the TCGA-LIHC on the basis of median expression of CD133, CD90, and EpCAM. Thirteen intersecting differentially expressed genes were identified, with high expression of TESC and QSOX1 being noted in LCSCs from spheroid cultures. B TESC’s high expression in the TCGA-LIHC was significantly correlated with shorter overall survival (OS). C TESC expression in various cancers compared with that in <t>adjacent</t> normal tissues (if available), assessed using TIMER2.0. D RNA expression of the TESC gene in <t>liver</t> <t>cancer</t> and normal liver tissues from the ICGC database. E Protein expression of the TESC gene in liver cancer and normal liver tissues from the CPTAC database. F Immunohistochemistry (IHC) image of TESC in liver cancer and adjacent liver tissues of <t>tissue</t> microarray (Cat. LV1505a, TissueArray.Com). Scale bar, 60 μm. * P < 0.05; ** P < 0.01; *** P < 0.001
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Association between TESC gene expression and clinical prognosis. A High and low expression groups, established by dividing the TCGA-LIHC on the basis of median expression of CD133, CD90, and EpCAM. Thirteen intersecting differentially expressed genes were identified, with high expression of TESC and QSOX1 being noted in LCSCs from spheroid cultures. B TESC’s high expression in the TCGA-LIHC was significantly correlated with shorter overall survival (OS). C TESC expression in various cancers compared with that in adjacent normal tissues (if available), assessed using TIMER2.0. D RNA expression of the TESC gene in liver cancer and normal liver tissues from the ICGC database. E Protein expression of the TESC gene in liver cancer and normal liver tissues from the CPTAC database. F Immunohistochemistry (IHC) image of TESC in liver cancer and adjacent liver tissues of tissue microarray (Cat. LV1505a, TissueArray.Com). Scale bar, 60 μm. * P < 0.05; ** P < 0.01; *** P < 0.001

Journal: Clinical and Experimental Medicine

Article Title: TESC associated with poor prognosis enhances cancer stemness and migratory properties in liver cancer

doi: 10.1007/s10238-024-01469-y

Figure Lengend Snippet: Association between TESC gene expression and clinical prognosis. A High and low expression groups, established by dividing the TCGA-LIHC on the basis of median expression of CD133, CD90, and EpCAM. Thirteen intersecting differentially expressed genes were identified, with high expression of TESC and QSOX1 being noted in LCSCs from spheroid cultures. B TESC’s high expression in the TCGA-LIHC was significantly correlated with shorter overall survival (OS). C TESC expression in various cancers compared with that in adjacent normal tissues (if available), assessed using TIMER2.0. D RNA expression of the TESC gene in liver cancer and normal liver tissues from the ICGC database. E Protein expression of the TESC gene in liver cancer and normal liver tissues from the CPTAC database. F Immunohistochemistry (IHC) image of TESC in liver cancer and adjacent liver tissues of tissue microarray (Cat. LV1505a, TissueArray.Com). Scale bar, 60 μm. * P < 0.05; ** P < 0.01; *** P < 0.001

Article Snippet: Human liver cancer with matched cancer adjacent liver tissue array was obtained from TissueArray.Com (Cat. LV1505a, USA).

Techniques: Gene Expression, Expressing, RNA Expression, Immunohistochemistry, Microarray